Na het vorige bezoek heb ik me verdiept in de trial voor het nieuwe medicijn waar ik mogelijk aan mee kan gaan doen. Gelukkig is alles openbaar en op internet te vinden. Ook de inclusie en exclusie criteria die zijn bepaald door de farmaceut die het medicijn op de markt wil brengen. Daarin las ik dat er wereldwijd voor deze trial maar 270 patiënten worden gezocht. Dat is wel heel erg weinig, en op mijn aandringen hebben we de intake-afspraak vervroegd.
Ben gewoon bang dat ik straks door de screening heen ben gekomen en dat men zegt “sorry, maar u bent nummer 271”.
Vandaag de intake gehad. Goede voorlichting en alle (inmiddels bij mij bekende criteria) worden doorgenomen. Zo moet het Hb onder de 6.2 zijn (was nu 5.7), de milt moet groot zijn en minimaal 5 cm onder de ribbenboog uit steken (voldoet), minimaal nog 6 maanden te leven hebben (gelukkig wel), en er moeten een aantal “secundaire” verschijnselen zijn zoals zware vermoeidheid, afvallen, verminderde eetlust en nog een aantal (heb ik ook).
Volgens de hematoloog voldoe ik zo op het eerste gezicht aan alle criteria die door de farmaceut gesteld zijn en we kunnen verder. Ter plekke onderteken ik een verklaring dat ik mee wil werken aan de trial en de bijbehorende onderzoeken. Een uitgebreid schema maakt onderdeel uit van de documentatie. De eerste vier weken na goedkeuring door de farmaceut iedere week een bezoek aan het ziekenhuis. Totaal in 36 weken 4 maal een MRI, 14 maal bloedonderzoek, 2 maal beenmergpunctie, 4 maal ECG. Ze houden je wel in de gaten met het testen van nieuwe medicijnen 😉
Als eerste moeten er nu metingen gedaan worden om definitief goedkeuring te krijgen van de farmaceut dat ik mee mag doen. De verschillende onderzoeken, waaronder een beenmergbiopt, worden nu ingepland. Het ECG (hartfilmpje) hebben we gelijk al laten maken.
De trial bestaat overigens uit een vergelijkende test. Door loting bepaalt men of je het medicijn mag uitproberen (2 van de 3 patiënten) of dat je in de groep valt die “de beste, beschikbare behandeling” krijgt (1 van de 3 patiënten dus zonder het nieuwe medicijn). Hopen dus dat ik mee mag doen met het nieuwe medicijn.
Ben blij dat er nu iets in gang wordt gezet. Er moet ook iets gebeuren want ik ga wel hard achteruit. Naast mijn vaste ochtendritme waarin ik energie spaar door vrijwel niets anders te doen dan TV kijken en krant lezen, moet ik nu ook aan het einde van de middag rusten om de dag verder door te komen. Vermoeidheid is een van de grootste problemen die ik heb. Hier kampen overigens alle Myelofibrose patiënten mee. De medicijnen zouden hierbij verbetering moeten geven. Laten we het hopen!
Bij deze controle is het Hb (energie) weer gezakt van 6.1 naar 5.7, maar zijn de plaatjes iets gestegen naar 98. De witte (weerstand) doen het nog steeds goed 7.3.
Binnenkort het vervolg van alle onderzoeken die nodig zijn om te bepalen of ik mee mag doen met de trial.
Toevallig precies nu een leuk boek aan het lezen. John Grisham “Claim”. Gaat over mega claims die advocaten bij farmaceuten neerleggen (uiteraard in Amerika) voor het op de markt brengen van medicijnen die niet deugen……
Não sou como tu João!Eu sou de Aveiro, não sou de Lisboa nem do PogmO.orrulho-te de ter estado em duas finais recentes e ter ganho uma!
me gustaria muchisimo que fuera de las elegidas como maravilla del mundo por que asi podriamos esta a la par con los demas paises…..Chichen Itza es el unico selecionado mexicano… hay que ganar, por honor…
I agree that there were larger forces at work in this election than just social media and that social media. Even if the McCain camp had rocked the social media world, I doubt it would have made a difference in the outcome of the election.
KJ już po spadkach EBC skupuje obligi zatem sztuczna hossa ale hossa zatem warto kupować. Szczególnie nasze akcje bo są mocno niedowartościowane. Mamy przed sobą 4 lata stałych wzrostów jak mi podpowiadają moje obliczenia. Do 2016 będziemy rosnąć i rosnąć z małymi korektami.
Just think Arturo, if you get ANOTHER nose job, you’re gonna have to walk around like this for a few weeks! No one will let a monster like you into any club no matter how much you sweet talk them!
You are my role model. In fashion, life, and overall fabulousness. Seriously.I also love wearing vibrant colors. I think it's the Indian in me. I would love to visit the country one day and witness all the magical colors for myself. Sigh. You're sooooo lucky! 🙂 xoxo
Hello Lokesh,I don’t think so,And I don’t want to argue with you ok..But i beg jagan to do something for people… and not for himselfAnd one thing Lokesh I am also from anantapur…:-)
As with any designer. You love to try something new. otherwise it will get boring. I remember doing a valentine table setting event. Instead of the usual color of pink and red. I went with a beige napkin with brown ribbon on a black charger. I ‘ll be happy to share photo if requested.
July 16, 2011 How often we ask “How are you?” when we really don’t care, and don’t want to know. .I have found that rather than have the answer all the time, the challenge is to really listen. Really care. And ask if there is a way for me to help. And mean it.Absolutely love the answer. We do look for the resurrection!! Praise Him!Thanks Glen,Craig
Genial!@Sascha Danke!@Ralf Ebenfalls danke. Ich denke, gäbe es nicht so viele Browser hätten wir möglicherweise weniger zu tun, aber die Webwelt wäre um einiges langweiliger. Es ist doch ganz gut so wie es ist, würde ich sagen.
Hi there! I could have sworn I’ve visited this blog before but after browsing through many of the articles I realized it’s new to me. Nonetheless, I’m certainly delighted I found it and I’ll be book-marking it and checking back often!
You’ve really helped me understand the issues. Thanks.
My problem was a wall until I read this, then I smashed it.
06/05/2011 – 12:29pmLas acusaciones al Barça de doping vinieron despues de una serie de reportajes en Marca acerca del dopaje. ¿Empezaremos a ver ahora este tema de la compra de partidos?Ahà lo dejo.
With all these silly websites, such a great page keeps my internet hope alive.
Kita tidak terkejut jika pasukan pembelaan akan sekali lagi mencari helah/diarah untuk menangguhkan perbicaraan. Namun agak pelik apabila seorang yang mengaku terhormat, warak dan bersih tampak begitu takut untuk menghadapi perbicaraan, sama takutnya untuk memberikan sampel untuk tujuan dna.
Snoopy Dance | “The Embassy of the United States in Cairo condemns the continuing efforts by misguided individuals to hurt the religious feelings of Muslims – as we condemn efforts to offend believers of all religions,”“Condemn…efforts” ≠“apology for 1st Amendment”…except in that parallel universe conservatives inhabit.And “Cairo Embassy” ≠“Obama”. You get more and more obtuse with every trope you repeat. Where do I get the RNC Dictionary with all the new definitions of common words and concepts?But it’s your lie…tell it any way you like.
jeanne,you are amazing.this piece was devastatingly beautiful… your perspective on death and dying, on life and living (because, as you so expertly show, they are irrevocably connected) is rare and amazingly soul-affirming. sharon gathered herself a menagerie of kindred spirits throughout her life, and her story (which is your story, which is their story, too, of course) is just…. unforgettable.thank you.so so much.for sharing sharon, for sharing your self.<3
Of the panoply of website I’ve pored over this has the most veracity.
None can doubt the veracity of this article.
Salla, kokeilepa uudestaan. Musta tuntuu, että osaisit arvostaa tätä kirjaa. :)Hilda Hussoa kannattaa taas tarkastella jo ihan rakenteen ja idean vuoksi, itsekin aion.
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i love, love, love everything about this look. (i wish she’d go easier on the make up because there’s no way anyone needs quite that much, but that’s a complaint i’ve had often about katy perry)
Light relief and enjoyable after the monthly Saga puzzle.The two 15 letter answers (top and bottom) were initially found, giving a good starting point for remainder of the grid.Favourite clue probably 26 across.
I thought finding this would be so arduous but it’s a breeze!
Eikö elukoista ole ikiajat käytetty kaikki irtoava hyödyksi? Miksi se nyt on yhtäkkiä paha asia jos makkaraan laitetaan kaikki syötäväksikelpaava? Jos näin ei olisi niin hipit olisivat itkemässä kun yhyyyy, Putesta ja Mansikista menee niin paljon hukkaan.
I live in Ireland and I buy all my natural products from iherb.com at great prices.For my skin I mixed and melted together: shea butter,cocoa butter with jojoba oil and coconut oil and I got a great moisturiser for face,body and hair.check the prices at iherb.com and if you’ll order, use cod KEB068 for 5 $ off on your first purchase.I got my package in just two days.really happy with everything I bought.just give it a try
– once the threat ceases to be a threat, the justification for lethal force ceases as well. Tam has actually had to draw her sidearm in her own defense before. If I had a choice, I'd rather have someone with her demonstrated self-discipline and her understanding of the use of lethal force in a Castle Doctrine state over someone with a cavalier "NOW can I shoot?" attitude in my platoon.gvi
20 augusti alltså, jag som nästan attackerade brevbäraren idag men sen surmulet fick gå in igen utan ikeakatalog. Jag får vänta lite till. Det är okej, jag har tydligen fått dille på att måla om lite här hemma, dörrkarmar och så.Kram
Deep thinking – adds a new dimension to it all.
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This makes me so happy! I love that they wanted to BE SEEN for her birthday. So awesome!And to Ari… I'm not even close to my 60s, but your blog is really inspiring for a younger person to wear awesome outfits at any age. People who see my collection of brightly coloured tights and shoes, and often comment, "Oh, I can't wear bright colours," and I ask, "WHY NOT?" And then I direct them to your blog. 🙂
Lieber das Buch, da steckt meistens deutlich mehr an Informationen drin. Photoshop habe ich seit Ewigkeiten nicht mehr upgedatet, da ich lieber auf dem iPad und ausser Haus zeichne 😉 Jetzt mit Adobe Touch und insbesondere Adobe Ideas komme ich aber wieder auf den Geschmack.
I have both a personal profile and a business page. Many of my business acquaintances send friend requests to my personal page. How can I redirect them to my page and/or is there a way to accept their friend request but then filter them so they don’t get all my personal stuff?
In general, pizza ovens are gas or electric styles or wood models. Coal even been used as a heat source. Wood fired oven pizza is excellent, some, but delicious pizzas can be prepared almost any style pizza oven. Try this incredible new discovery: Cone Pizza!
RainiApril 11, 2010Whoops – I should clarify. I’ve bought Blue Skies in ebook form from Books on Board. I thought I’d check there just in case – they seem to have everything at that site.
Wow, your post makes mine look feeble. More power to you!
I saw another execution over the weekend. Similar (or maybe the same?) group of guys stuck in a tent in the Antarctic like Scott. They don’t want to go out until one of the gang reminds the rest it’s his birthday. Again, it’s better than the starlings. But I agree with Anonymous 2:02 – ’Belong’ would be have more impact without the heavy-handed end line.
When we were growing up we would have an easter egg hunt and the eggs had pennies inside of them. Anywhere from 1-3 pennies. The big winner egg was an egg that had a 50 cent piece in it. My brother would always find it.
na FW20 jeżeli przejdziemy ten dołek fali 1 to znaczy że zrobiliśmy 4 fale korekte abc i czas zrobić 5tą fale na nowe szczyty i dopiero wtedy według mnie korekta
If you’re looking to buy these articles make it way easier.
Is that really all there is to it because that’d be flabbergasting.
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Phil – please have a read of this article by Joseph Massad and let us know if you still think Obama is a love machine. I’m not convinced.Note the article’s sub-title: Although Palestinian children endure lives of suffering, Obama’s love for their Israeli counterparts knows no limit.
I came, I read this article, I conquered.
Guy Môquet nous a fait perdre la tête. C’est une victoire posthume et pour cette fois les communistes étaient du côté argentin (qui n’ont plus de junte).La prochaine fois on jouera aux Malouines. A balles réelles ?
I really wish there were more articles like this on the web.
Yes – thanks for the advice, dearest Eric, March inches forward, slowly does it… Yesterday was offered some interesting, well-paid work, but won’t see any pay till December (I should live so long..!). Of course, I accepted it – but I’m hanging on in there, am sure there’s more to come – slowly does it, faith and patience.
All the ads for “Country Strong” and it did not even get 1,500 theaters? I have to ask is her song being played on country music stations? Could surprise in midwest/south I guess.I have to agree with Chuck, saving money for Green Hornet, just hoping it can get even average reviews.
Boom shakalaka boom boom, problem solved.
Unhas das caracterÃsticas dos superfluÃdos é que poden atravesar obxectos sólidos e superficies non porosas debido á súa gran capacidade de oscilación. Por outra banda, o xeo quente fórmase a partir da rápida cristalización dunha disolución hiper-saturada, que posteriormente se arrefriou, de acetato de sodio e auga quente.
Burma in public in Rangoon, Burma, a city where you can find halal shops everywhere..Now the women's group Akhaya think they may have found a solution. Women blow their flute as soon as they feel the harassment. This will alarm the other bus passengers who can come to the women's rescue.Norwegian Church Aid helps out with the flute project.Something to think about also for Europe?
Thanks for your thoughts. It’s helped me a lot.
Keep on writing and chugging away!
That’s a creative answer to a difficult question
Absolutely first rate and copper-bottomed, gentlemen!
Absolutely first rate and copper-bottomed, gentlemen!
TuttoVolume scrive: 11/09/2009 alle 09:47Ne esistono anche del tipo che permettono di registrare e tagliare. Non ricordo bene il nome, ma mi sembra si chiami Audiko.Grazie Marco Rispondi
Me and this article, sitting in a tree, L-E-A-R-N-I-N-G!
can i say you and tavi are long lost bestfriend? because i think you both have lots of same thing. and you both amazing! i love what you do tih that journal, and those words are really inspiring 🙂 x
Ja bym to ujÄ…Å‚ tak: Tamci sÄ… jeszcze gorsi. I to znacznie. Tym bardziej my mamy obowiÄ…zek prostowania tych tutaj. Jesli nam siÄ™ nie uda – to faktycznie przed nami 600 lat pracy organicznej.
That’s a shrewd answer to a tricky question
I much prefer informative articles like this to that high brow literature.
bonjour chère Nathalie, ah cette poste a bien décrit la protection et l'amour de la famille.c'est magnifique.ps, j'adore les rues haha.belle journée magique.HUGS
Thanks for the advice. We've had such a race to the bottom in so many fields (I'm a trial lawyer — I'm sure you know how horrid and spammy that gets), that's it good to see action taken in reducing the effect of re-writing news stories as 250 word blog posts with targeted anchor text.As I'm sure you agree, there's still lots work to do, but I think you're on the right track.
Deadly accurate answer. You’ve hit the bullseye!
I came, I read this article, I conquered.
I much prefer informative articles like this to that high brow literature.
So that’s the case? Quite a revelation that is.
John Mansfield–because none of the adults’names were ever turned over to police. THAT would have been the appropriate child-protective course of action, not writing their names in a file and telling them, essentially, to move along. Professionals who work with children (doctors, teachers, etc) are MANDATED REPORTERS: we MUST inform the police if we have reason to suspect child abuse. It is unlawful for us not to. Yes, it turns up a number of false positives. But it is a safer alternative to just hoping it doesn’t happen again.
This introduces a pleasingly rational point of view.
You really saved my skin with this information. Thanks!
May 14th, 2008 at 10:13 am# 80 You may be right that the numbers cannot be dismissed out of hand. Nevertheless, I remain wary, given the pressure on developers to discount and move units, homeowners pushed into short sales, etc. I guess I am back to the position taken by Reagan some years ago: ДоверÑй, но проверÑй (doveryai, no proveryai). It will be interesting to see some granular analysis of the data.Правильной дорогой идете, Товарищ!!!
What a pleasure to find someone who thinks through the issues
Great feature ! I was triing to show connection types on a same report (modem, adsl etc..), but found that this data was gone. It would be great to be able to see average load times by connection device (modem,adsl etc…).
Perfect shot! Thanks for your post!
Thinking like that is really amazing
Holy shiznit, this is so cool thank you.
I’m not that much of a online reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your site to come back down the road. Many thanks
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De departe faza cea mai trista e ca oriunde te duci e la fel. Arata-mi un operator cu servicii ok si o banca care sa nu-si bata joc in Romania si maine ma duc cu sarsanalele la ambele.
This website makes things hella easy.
C’est bon j’ai enfin vu le pilot de ces 3 nouvelles séries, et je pense que la seule que je vais continuer va être Arrow, le premier épisode est convaincant avec quelque petite faiblesse, reprendre le chateau des Luthor de Smallvlle était un peu gros mais bon ils ont apparemment changé l’intérieur. Concernant Beauty and the Beast, pilot très moyen même si j’ai toujours aimé Kristin Kreuk sa sera sans moi et Emily Owen M.D était effectivement du sous Grey’s Anatomy
I cannot tell a lie, that really helped.
Mình vừa check lại link thấy ổn mà cáºu, nếu ý cáºu nói link từ táºp 7 đến táºp 12 thì không phải bị die đâu, là do bị chặn thôi. Cáºu nên và o link folder, save file vá» acc riêng của cáºu thì má»›i download được >v<
What a pleasure to find someone who thinks through the issues
A provocative insight! Just what we need!
Wow! Talk about a posting knocking my socks off!
Sinusta “AI” on ok jos Raamattua erehtymättömänä pitävä kasvatustieteen (jota kaikki opet joutuu opettelemaan yliopistoissa) proffa haistattaa luonnonhistoriaa koskevalle luonnontieteelle pitkät (koska ristiriidassa Raamatun sanan kanssa) ja toivoo (Raamatullisen) luomisopin saavan jalansijarakoa kouluissa tiedetunneilla vähän kuin keskiajalla.. ??”Perimmäinen tarkoitus” on luettavissa myös kaikista muista TP:n sanomisista Kalevassa, uskonsaittien haastatteluissa ym.Ei pelkän kirjan varassa tarvi.. tyhymä sinisilimä oot jos niin meet maailman läpi.Skepsis ei oo sinisilimä niinku sä.
Shoot, so that’s that one supposes.
Daniel / Acho que pode acabar, do geito que anda as coisas deve acabar mesmo… super população, temperatura aumentando, se nao acabar vai ser tenso viver daqui 40 anos.
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I remember that movie. Wasn't that the one where Troy had a band called Hey, That's My Bike? I remember the scene where the car windows exploded due to the very loud stereo! Some funny moments there. [ .fqkj{position:absolute;clip:rect(445px,auto,auto,488px);}approval ]
This is the perfect post for me to find at this time
A little rationality lifts the quality of the debate here. Thanks for contributing!
Holy shiznit, this is so cool thank you.
Apparently this is what the esteemed Willis was talkin’ ‘bout.
First time reader,found you through the new Bourque site, BC Newswatch. I need your address to send you a bill since I have spent the last two hours reading through your work instead of doing mine. Fantastic – compelling and in some cases top notch investigative work that should be page 1 section 1. Glad to have made the aquaintence, nice to have another west coast place to stop. I’m on the Hill, and this is a view I haven’t seen before. Cheers!
That’s not even 10 minutes well spent!
He’s completely beat to shit; the team doesn’t want him there anymore; his coach is on the doorstep of unemployment; and the owner is bleeding money…..He might as well jump ship now…it would only be more humiliating the longer he goes.At best they get 5 maybe 6 wins….What’s the point.Plus, he needs to get prepared for this messy divorce that’s coming.
Noen ganger er turer bra, andre ganger ikke, jeg er litt opp og ned der…..f eks var det i gÃ¥r veldig behagelig Ã¥ kjøre rundt pÃ¥ viddene i en løypemaskin, istedenfor Ã¥ ta skiene fatt……masse fin natur, men godt og varmt……Synes du var lur som sendte mann og barn ut, sÃ¥ du selv kunne nyte livet til det du selv ville.Ha en god søndag.
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It’s about time someone wrote about this.
Jajaja… cierto, lástima que Nini no grabó el momento “empujón a mochila de Presi-Presi-niño”, eso sà que fue de pesadilla de corto. Te debo unas birras.
And I thought I was the sensible one. Thanks for setting me straight.
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A quien hay que matar para tener una casa asÃ? Bueno esta biennnnn matar es muy grave… vale con herir levemente ;)Bsnes
I don’t know who you wrote this for but you helped a brother out.
Yeah! Rock n’ Roll! Another great workout and a great series of videos! And you’ve definitely put on some size! You seem to have lots of energy Kev. Love the words of wisdom.Just awesome. What more can I say. I’m off to do legs in a few hours. Hardly ever been so excited about going to the gym.Now get some rest and grow!!
Thanks for sharing. What a pleasure to read!
Thanks for starting the ball rolling with this insight.
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If you advocate for the diminution of consent of the governed (as occurs with the single-state proposal), then you are not progressive, not supporter of democracy, but supporter of something more sinister (civil war and tyrrany of the majority).
Hallo Manu,sehr schöne Waldfotos zeigst du uns. Da bekommt man Lust auf einen Waldspaziergang. Ich hoffe am Wochenende regnet es nicht. Dass man mal länger vor die Tpr kann.Dir und deiner Fam.ein superschönes, hoffentlich sonniges WochenendeLgBarbara
Just to be clear, The Stephen above is not me, Stephen B., me being the person active in the blog discussion over the past few weeks.Not that I agree or disagree with anything in particular above.
You know what, I’m very much inclined to agree.
AFAIC that’s the best answer so far!
This is the perfect way to break down this information.
Now I feel stupid. That’s cleared it up for me
It’s not as if the Tales series hasn’t had magical swords as characters before – it was a major part of Tales of Destiy after all. The sacrificial girl is an unfortunate recurring toxic trope in JRPGs (and elsewhere) however so it’s good to point it out. It sounds like Collette is heading down the same path as Aeris from FF7, Mina from Breath of Fire 2, Lucia from Lunar: Eternal Blue and numerous others.
Wow I must confess you make some very trenchant points.
Begun, the great internet education has.
I don't know … my kids swim on a club swim team. It is very much an individual sport with the team/friends aspect. Girl child is taking up junior roller derby too. It is a team sport and a little quirky and lots of fun.
Way to go on this essay, helped a ton.
What a neat article. I had no inkling.
Ooh I hate when I forget to bring a snack places! Those pb crackers look pretty good. Good choice!! And as much as I looove cereal, it doesn’t fill me up. I usually have it as a snack instead now, rather than for breakfast!
Superior thinking demonstrated above. Thanks!
It’s always a relief when someone with obvious expertise answers. Thanks!
Very valid, pithy, succinct, and on point. WD.
Okay so here i am trying to get my link fixed. How do you like me doing this via your comment section??? Do you still love me?? cross your fingers, otherwise I will be back!!!
Normally I’m against killing but this article slaughtered my ignorance.
AFAICT you’ve covered all the bases with this answer!
At last, someone who knows where to find the beef
A piece of erudition unlike any other!
Les médecins sont en pointe sur ce sujet même si, vous l’avez compris, l’ensemble de la communauté scientifique se sent concernée. Les médecins sont en pointe car beaucoup d’entre eux ressentent qu’ils ont le devoir de protéger la société contre le charlatanisme. C’est bien le cas quand des peurs sont agitées à partir d’études non concluantes ou lorsque des associations recrutent des militants sur les basses d’allégations de santé mensongères.
Instead of having to click a link to see more comments, why not just display the additional comments on the page? That would seem to be the most efficient and the most easiest way to do it.
Christina, not to worry at all. Thanks for the link, I will also reciprocate!Unfortunately I never get confused for Freja, although I was secretly pleased when I discovered we shared the same name: she has become one of my favourite contemporary models.Once again, many thanks!Freya
If time is money you’ve made me a wealthier woman.
These topics are so confusing but this helped me get the job done.
Going to put this article to good use now.
jag vill vinna för att jag aldrig har sett det men har velat se det sååå länge! 🙂 dessutom är jag inne i en jobbig tentaperiod sÃ¥ det här hade ju muntrat upp mig!
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